Neurovascular disorders are strongly related to each other. Blood vessels depend on healthy nerve activity, and healthy blood flow is necessary for healthy nerves. Narrowing of the blood vessels is the first pathological change in the tiny blood vessels. The development of blood vessel abnormalities, such as capillary basement membrane thickening and endothelial hyperplasia, which lead to decreased oxygen tension and hypoxia, and neuronal dysfunction as the disease advances are strongly correlated.
An known feature of diabetic neuropathy is neuronal ischemia. Blood artery opening medications (such as ACE inhibitors and 1-antagonists) can significantly increase neuronal blood flow and speed up nerve conduction. The severity of the structural, functional, and clinical abnormalities seen in Diabetic Neuropathy may therefore be supported by the fact that small blood artery malfunction develops early in diabetes, follows the evolution of brain dysfunction, and may even be sufficient to support them.
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