Persistent discomfort affects 10% or less of diabetes individuals. In Diabetic Neuropathy, pain may be sudden or stimulus-induced, intense or unmanageable. Diabetic Neuropathy pain is frequently worst at night and can be described as a burning, stinging, shooting, aching, jabbing, sharp, cramping, tingling, chilly, or allodynia. Early in the course of diabetes, some individuals experience the onset of mostly small fibre neuropathy, which manifests as pain and paresthesia and may be related to insulin administration (insulin neuritis). It only lasts for less than six months, the symptoms are worst at night, and the feet are more affected than the hands.
Acute Diabetic Neuropathy cachexia has been used to describe DN discomfort that is occasionally accompanied by depression and weight loss. Mostly affecting men, this condition can develop at any point throughout the course of both type I and type II diabetes. It self-limits and is responsive to symptomatic therapy. Amyloidosis, heavy metal toxicity, Fabry's disease, and HIV should be ruled out in these patients.
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