Single-use Biomanufacturing Industry Potential for Growth till 2030

Single-use Biomanufacturing Industry Data Book Covers Single-Use Bioprocessing, Bioreactor, Assemblies & Filtration Assemblies Markets.

Grand View Research’s Single-use Biomanufacturing Industry data book is a collection of market sizing & forecasts insights, market dynamics & trends, opportunity assessment, regulatory & technology framework, pricing intelligence, competitive benchmarking analyses, and macro-environmental analyses studies. Within the purview of the data book, such information is systematically analyzed and provided in the form of summary presentations and detailed outlook reports on individual areas of research.

Single-use Bioprocessing Probes And Sensors Market Insights

The global single-use bioprocessing probes and sensors market size was valued at USD 1.9 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 13.9% from 2021 to 2028.

Being an integral part of a single-use container, pH sensors held the major revenue share of 20.9% in 2020. High product penetration and usage rate have attributed to this large share. Technological advancements in this sensor type, such as the development of a pH sensor with an in-built temperature sensor, are expected to drive the segment.

The upstream segment dominated the market for single-use bioprocessing probes and sensors and accounted for the largest revenue share of 74.2% in 2020. Adoption of single-use bioreactors and media bags by bio manufacturers in the upstream manufacturing process has significantly increased the usage of sensors in this segment.

The biopharmaceutical manufacturers segment dominated the market for single-use bioprocessing probes and sensors and accounted for a major revenue share of 58.9% in 2020. Constant new product developments and accelerated adoption of disposables among contract service providers as well as in-house bio manufacturers to meet the growing global demand for biopharmaceuticals efficiently is one of the major factors for the growth of this segment.

OEMs such as Sartorius Stedim Biotech, GE Healthcare are at the forefront in innovation for single-use assemblies using products from independent suppliers. Suppliers like PendoTECH are involved in selling a substantial volume of its sensors and monitors to OEMs for GMP production, pilot and toxicology studies, and clinical batches.

Single-use Bioreactors Market Insights

The global single-use bioreactors market size was valued at USD 3,304.1 million in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 17.19% from 2023 to 2030.

The single use bioreactor systems segment captured the largest market share of above 81.17% in 2022. Single-use bioreactor systems are widely used in biopharmaceutical manufacturing processes that require high product yield. The versatility, cost-effectiveness, and high mass production capability of single-use bioreactors would increase demand for the products leading to rapid market growth.

Stirred tank bioreactors accounted for the largest share of 80.18% in 2022. The benefits offered by these bioreactors include good oxygen transfer and fluid mixing ability, easy scale-up, low operating costs, compliance with cGMP requirements & alternative impellers. These factors have led to the highest penetration of stirred tank bioreactors in the market.

The mammalian cells segment accounted for the largest share of 80.80% in 2022. This can be attributed to the significant penetration of this cell type in the creation of biopharmaceutical therapies and the commercial success of recombinant proteins made from mammalian cells. As per BioProcess International, 85.0% of biopharmaceutical candidates in clinical development are made using mammalian cell cultures.

The vaccines segment accounted for the largest share of 27.92% in 2022. This is majorly attributed to the COVID-19 outbreak, which has resulted in an urgent need for the development of virus vaccines. According to Bioplan Associates, the use of single-use systems in the commercial manufacturing of vaccines is anticipated to rise sharply.

In 2022, the research and development (R&D)/process development segment accounted for an 80.27% share of the market. Single-use bioreactor utilization in process development is a driving force behind market expansion. For instance, according to an article published in 2020 by American Pharmaceutical Review, the industry has employed about 71.2% of single-use bioreactors for process development.

The lab-scale production segment held the largest revenue share of 35.69% in 2022. In the biopharmaceutical business, disposable bioreactors are frequently employed in preclinical & clinical research. It is anticipated that growing single-use technology acceptance would have a substantial impact on segment growth in cell-based therapy research and vaccine production.

The CMOs & CROs segment accounted for a significant share of 38.64% in 2022 and it is also expected to be the fastest-growing segment during the study period. The demand for supply production capacity as well as quick awareness campaign change-overs is more among CMOs. As a result, they use a broader range of single-use components and systems. With the increasing trend of outsourcing, CROs & CMOs are more likely to adopt single-use bioreactors.

Access the Global Single-use Biomanufacturing Industry Data Book, 2022 to 2030, compiled with details like market sizing information & forecasts, trade data, pricing intelligence, competition benchmarking, macro-environmental analyses, and regulatory & technological framework studies

Single-use Assemblies Market Insights

The global single-use assemblies market size was valued at USD 10,232.8 million in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 18.60% from 2023 to 2030.

The filtration assemblies segment held the highest share of 29.22% of the overall revenue in 2022. Increased regulatory prospects and the need to diminish the risk of contamination have promoted the use of filtration assemblies for bulk and final fill operations. Single-use filtration assemblies are a flexible and efficient alternative to stainless-steel systems as they eradicate sterilization steps and the related validation protocols.

The filtration segment dominated the industry in 2022 and accounted for a revenue share of 28.70% of the overall revenue. The implementation of single-use assemblies for filtration is rapidly increasing owing to their benefits infiltration. SUTs save not only expense and time, but also 90% of integrity testing, 90% of sterile connections, and up to 90% tubing time. Single-use flirtation systems also save process time as it is ready to use, unlike conventional filtration systems. 

The cell culture & mixing segment is expected to register the fastest CAGR of 20.33% from 2023 to 2030. The growth is mainly driven by the rising demand for biopharmaceuticals, favorable governmental policies, and increasing investment in R&D.

On the basis of solutions, the global industry has been categorized into customized solutions and standard solutions. The customized solutions segment dominated the global industry in 2022 and accounted for the largest share of 71.47% of the overall revenue. With a single order, pharmaceutical companies, labs, and other end-users can effortlessly integrate the systems into their process, coupled with streamlining production, and reducing the hassle of sterilizing and cleaning. 

The biopharmaceutical & pharmaceutical companies segment dominated the global industry in 2022 and accounted for the highest share of more than 45.61% of the overall revenue. The growth of the current manufacturing facilities for biopharmaceuticals drives the demand for single-use assemblies.

Single-use Filtration Assemblies Market Insights

The global single-use filtration assemblies market size was valued at USD 2,989.7 million in 2022 and is expected to expand at a compound annual growth rate (CAGR) of 18.70% from 2023 to 2030.

The membrane filtration segment accounted for the largest share of over 47.8% in 2022. This growth can be attributed to the increasing adoption of filtration systems by various industries. Membrane filtration sub segmented into TFF and Direct Flow Filtration (DFF) /dead-end filtration /normal flow filtration. Within this segment, Tangential Flow Filtration (TFF) accounted for the largest share of 59.9% in 2022.

The bioprocessing/biopharmaceuticals market segment dominated the market in 2022, accounting for over 41.6% and also held the fastest revenue share. This growth can be attributed to the increasing research and development funding for the development of biopharmaceutical products. For instance, in October 2021, National Institute for Innovation in Manufacturing Biopharmaceuticals (NIIMBL) of the United States granted funding of USD 3 million for 6 new biopharmaceutical manufacturing project.

The filter segment dominated the market and held the largest revenue share of 21.1% in 2022 Single-use filters are one the most popular and widely used single-use technologies. The efficiency of depth filters during clarification processes can be increased by using flocculating agents, filter aids, and protective profilers.

Single-use Biomanufacturing Market – Global Industry Segmentation

Single-use Biomanufacturing Market - Segment Analysis, By Product, 2018 - 2030 (USD Million)

• Simple & Peripheral Elements
  1. Single-use Assemblies, By Product
     1. Bag Assemblies
        1. 2D bag assemblies
        2. 3D bag assemblies
     2. Filtration Assemblies
        1. Membrane Filtration
           1. Tangential Flow Filtration (TFF)
              1. Ultra/Diafiltration
              2. Micro-Filtration
           2. Direct Flow Filtration (DFF) /Dead-end Filtration /Normal Flow Filtration
        2. Depth Filtration
        3. Centrifugation
        4. Others
     3. Bottle Assemblies
     4. Tubing Assemblies
     5. Other Products
  2. Single-use Assemblies, By Solutions
     1. Customized Solutions
     2. Standard Solutions
  3. Probes & Sensors
     1. pH Sensor
     2. Oxygen Sensor
     3. Pressure Sensors
     4. Temperature Sensors
     5. Conductivity Sensors
     6. Flow Sensors
     7. Others
  4. Others
• Apparatus & Plants
  1. Bioreactors, By capacity
     1. Up to 10L
     2. 11-100L
     3. 101-500L
     4. 501-1500L
     5. Above 1500L
  2. Bioreactors, by Type
     1. Stirred-tank SUBs
     2. Wave-induced SUBs
     3. Bubble-column SUBs
     4. Other SUBs
  3. Mixing, Storage, & Filling Systems
  4. Chromatography Systems
  5. Pumps
  6. Others
• Work Equipment
  1. Cell Culture System
  2. Syringes
  3. Others

Single-use Biomanufacturing - Segment Analysis, By Workflow, 2018 - 2030 (USD Million)

• Upstream Bioprocessing
• Fermentation
• Downstream Bioprocessing

Single-use Biomanufacturing Market - Segment Analysis By End-use, 2018 - 2030 (USD Million)

• Biopharmaceutical Manufacturers
  1. CMOs & CROs
  2. In-house Manufacturers
• Academic & Clinical Research Institutes

Order your copy of the Free Sample of “Single-use Biomanufacturing Industry Data Book - Single-Use Bioprocessing, Bioreactor, Assemblies & Filtration Assemblies Market Size, Share, Trends Analysis, And Segment Forecasts, 2022 - 2030” Data Book, published by Grand View Research 

Single-use Biomanufacturing Industry Data Book Regional Outlook

• North America
  1. U.S.
  2. Canada
• Europe
  1. U.K.
  2. Germany
  3. France
  4. Italy
  5. Spain
  6. Russia
• Asia Pacific
  1. China
  2. Japan
  3. India
  4. South Korea
  5. Singapore
  6. Australia
• Latin America
  1. Brazil
  2. Mexico

• Argentina

• Middle East & Africa (MEA)
  1. South Africa

• United Arab Emirates
• Saudi Arabia

Single-use Biomanufacturing Industry Data Book Competitive Landscape

Competitive rivalry in the single-use bioprocessing market is high due to the presence of a substantial number of both well-established companies and small- to mid-sized companies as well as CROs in the industry.

Key players operating in the single-use biomanufacturing industry are –

• Thermo Fisher Scientific, Inc.
• Sartorius AG; Corning, Inc.
• Eppendorf AG; PBS Biotech, Inc.
• Avantor, Inc.
• Entegris, Inc.
• Kuhner AG
• MEISSNER FILTRATION PRODUCTS, INC.
• Danaher Corporation
• Merck KGaA.
• Boehringer Ingelheim
• Lonza
• AGC Biologics (CMC Biologics)
• Rentschler Biotechnologie GmbH.

Go through the table of content of Single-use Biomanufacturing Industry Data Book to get a better understanding of the Coverage & Scope of the study

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