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A folate antagonist is methotrexate. One of the most well-known and efficient drugs for treating inflammatory kinds of arthritis is methotrexate. One of the safest medications for arthritis is this one. Psoriasis and rheumatoid arthritis can both be treated with Methotrexate Drugs. In addition, methotrexate is used to treat a variety of cancers, including as leukaemia, breast cancer, lung cancer, some types of head and neck cancer, and cancers that start in the uterine tissues that surround a fertilised egg (cancer that begins in the white blood cells). Your immune system is calmed by methotrexate, preventing it from attacking the cells in your body. This lessens inflammation, which contributes to psoriasis' thicker skin, rheumatoid arthritis' swollen and stiff joints, or harm to the body.