与整个气雾剂产品相比，气雾剂阀门可以说是“一人守关，万人过不去”的一个非常重要的点。它不仅关系到产品的密封性，还关系到顶出效果，也关系到产品的稳定性。今天我就简单谈谈20mm气雾阀（不包括二元阀袋）在研发设计阶段应该如何操作。
气溶胶阀的类型和结构
我们从使用上来分类，因为前两个是常用的阀门，就不多介绍了，直接上图：
标准阀门，即正常注射使用的阀门：
360阀是一种可以直喷也可以倒置喷的阀门，但并不是真正意义上的360°阀门。当有一定的角度时，它只能喷射推进剂，不能同时喷射气体和液体：
全向阀是真正意义上可以360°任意角度喷射的阀门。它可以是直立的、倒置的和水平的。国内使用较少，主要用于高档化妆品。这种类型的阀门底部有一个阀杆。一个悬垂，当你倾斜到任何角度时，悬垂都会落到罐子里的最低位置。当按下按钮时，阀通道打开，可以任意角度弹出。
气溶胶阀选型要点
The choice of sealing cup material: the thickness of the iron cup is usually 0.27mm, the thickness of the aluminum cup is usually 0.42mm, and the two materials can be used in the form of materials, and can also be used with layers of different materials. The commonly used ones are introduced below. Sealing cups of several materials:
The choice of gasket material: gaskets are usually divided into inner gaskets and outer gaskets. They are made of various materials, mainly: Buna, chloroprene, butyl, chlorobutyl, nitrile, chloroprene, polyurethane, etc. .
According to the different materials and propellants, choose the right material to adjust the ideal formula. You can also consult the valve supplier for the applicability of the material, which is a good way for beginners to speed up the development process. Different valve suppliers have different levels, so you can consult some top valve suppliers.
General recommendations: diner (water-based, alcohol-based), chloroprene (oil-based, solvent), butyl (DME, strong solvent), etc.
Selection of stem aperture: common sizes are 0.33, 0.41, 0.46, 0.51, 0.61mm, and the number of stem holes is one of the determinants of the ejection rate. There are also different series of the number of stem pores, there are 1, 2, 4, 6 and even 8 holes.
Selection of gas phase bypass hole: The gas phase bypass hole is located on the valve chamber body, and the valve is located inside after the valve is sealed. It is mainly used to increase the atomization effect, increase the ejection stability of the content of some powder products, and increase the ejection of high-viscosity products, etc. Features. There are single-hole and double-hole designs.
Selection of the length of the dip tube: the length of the dip tube can be set according to
Valve length = total height of tank-experience value
(The length of the valve is usually the length from the horizontal line of the valve cup to the bottom of the dip tube). Then through the compatibility test, the shrinkage of the dip tube in the product is collected, and the valve height is finally determined. For the final valve length, it is better that the bottom of the dip tube is at the lower 1/3 of the semicircle of the bottom of the tank after the immersion is stable.
Aerosol valve compatibility test
Test the following points as the key test items:
1. Stability test of sealing cup material
2. Swelling test
3. Weight test
4. Hardness test
5. Dip tube length test
6. High and low temperature test of powder products
Tips for aerosol valve
1. There is a shrinkage phenomenon in alcohol, whether it is a gasket or a dip tube, pay attention to the existence of this possibility.
2. Do not test in the concentrated liquid. The materials in the concentrated liquid are often stronger than those in the diluent, and the data obtained does not meet the requirements of the finished product.
3. Burning identification of inner gasket material:
Chloroprene: Can not continue to burn away from the fire source, the flame is yellow
Dinner: After leaving the fire source, it can continue to burn, expand, the surface is charred, and the flame is yellow.
Butyl: After leaving the fire source, it can continue to burn, twist, crack, and the flame is yellow
Chlorobutyl: can continue to burn after leaving the fire source, the inner hole becomes larger, radial cracks, and the flame is yellow
How to use aerosol valve correctly
Pressure metered aerosol inhaler
The pressure metered aerosol inhaler is composed of three components: medicine, propellant, surface active substance or lubricant. The aerosols that use this inhalation device include Ventolin aerosol, Chuankangsu aerosol, Aquanle aerosol, becodone aerosol, cosdone aerosol, and Pulmicort aerosol. Wait. The usage method is: ①Remove the cover of the sleeve mouth, and shake the medicine tank gently to mix it before use. ② Tilt your head back slightly and exhale slowly, exhaling the air in your lungs as much as possible. ③ Hold the inhaler mouthpiece tightly in your mouth, hold your breath, press the inhaler tightly with your index finger and thumb to release the medicine, and at the same time do a slow and deep inhalation synchronized with the spray, preferably more than 5 seconds ( Some devices have a flute sound, and no flute sound means that the medicine has not been inhaled). ④ Try to hold your breath for 5-10 seconds to fully distribute the medicine to the lower airway to achieve a good therapeutic effect. ⑤ Put the cover back on the spout. ⑥ Rinse your mouth with water to remove the residual medicine in the upper pharynx.
Dry powder inhaler
The dry powder inhaler uses the kinetic energy of the user to actively inhale air to disperse the drug particles, and the flow rate of the dry powder mist particles is consistent with the user's inhalation flow rate. There are three types of dry powder inhalers commonly used in China: the storage-dose vortex dry powder inhaler, commonly known as Dubao, and the other is the rotary butterfly dry powder inhaler. The third type is the quasi-acceptor.
How to use Dubao: ①Rotate and remove the cap. ②Check the dose indicator window to see if there is enough dose of medicine. ③Take Dubao in one hand and hold the bottom cover in the other hand. Turn to the right and then to the left until you hear a "click" to complete one dose of filling. ④ Before inhaling, exhale gently (do not blow into the mouthpiece), put the mouthpiece in your mouth, and take a deep breath to complete an inhalation action. ⑤ Hold your breath for about 5-10 seconds after inhaling the medicine. ⑥Close the cap tightly after use.
How to use the rotary butterfly dry powder inhaler: This type of inhalation device is specially designed for inhalation and is equipped with a butterfly inhaler. Each vesicle of Biketone butterfly and Chuanning butterfly contains a very small corresponding drug, which is protected by a double-layer foil, and 8 vesicles are regularly distributed on the butterfly. When in use, put the butterfly disc into the rotary butterfly dry powder inhaler, the needle on the inhaler will pierce a small bubble on the butterfly disc, and put the medicine powder inside in the butterfly inhaler, the patient only needs to inhale gently (Even if the inhalation rate is extremely low), the medicine can be delivered to the lungs. It is also very easy to operate for children and the elderly.
How to use the applicator: ①Hold the applicator shell with one hand, and push the sliding rod of the applicator outward with the thumb of the other hand until it clicks, indicating that the applicator is ready to inhale medicine. ②Hold the applicator and keep it away from the mouth. Exhale as much as possible while ensuring a stable breathing. ③Put the mouthpiece in your mouth, inhale deeply and steadily, inhale the medicine into your mouth, and hold your breath for about 10 seconds.④Take out the applicator, slowly resume exhalation, and close the applicator (a click sound means it is closed).
Summary
The choice of aerosol valve is not simply to get a sample from the supplier, and then package and stability test can be done, but according to the physical and chemical characteristics of the product developed by the research and development engineers set what they want and need Material, and then through the selection of different suppliers, you can first obtain the technical parameter table of the corresponding valve, according to the parameter table, you can simply read the useful information and the pre-judgment of whether the functionality can be satisfied, and then according to the price of the product and the supplier’s Grade, select reasonable samples for proofing, compatibility testing and stability testing.
请注意，这并不意味着阀门密封杯的材料必须与气雾罐的材料相同。研发人员可根据产品特性进行设置，并通过稳定性测试进行验证。
还建议您可以向供应商索取不同材质的垫片、阀杆、弹簧、阀壳、汲取管等，并建立自己的数据库，以便日后需要时，可以快速阅读资料并选择你需要什么材料。
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