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What is Hormone Replacement Therapy (HRT) and the Risk of Venous Thromboembolism (VTE)?
Hormone Replacement Therapy

For the treatment of menopause symptoms, Hormone Replacement Therapy (HRT) is employed. You may decide to use hormone treatment based on your age, family medical history, personal medical history, and the severity of your menopausal symptoms. Discuss the advantages and disadvantages of HT, its various forms, and other available alternatives with your doctor.

VTE, which includes pulmonary embolism and deep venous thrombosis, increased by double (HR = 2.06) in the WHI CEE/MPA arm. Numerous European research have shown that transdermal estradiol does not carry the same thromboembolic risk. According to the French ESTHER study, the total chance of developing a blood clot is 0.9, which represents a reduced risk. These conclusions are supported by other research that examined various transdermal estradiol dosages and administration methods, with at least no influence on the risk of blood clotting.

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