In WD + PDX mice, relative abundance of the taxa Allobaculum, Bifidobacterium, and Coriobacteriaceae linked with the lean phenotype increased, according to microbiome analyses. In the duodenum, jejunum, ileum, and colon of WD + PDX mice, gene expression analysis using a linear mixed-effects model consistently revealed downregulation of Dgat1, Cd36, Fiaf, and overexpression of Fxr. According to Spearman correlations, enriched genera in WD + PDX mice had inverse relationships with fasting lipids, downregulated genes Dgat1, Cd36, and Fiaf, and positive relationships with upregulated genes Fxr. These findings imply that Polydextrose caused systemic alterations in mice fed WD through control of the intestinal tract's gene expression and gut flora.
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